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A 57 year old female patient complained of repeated blinking of the right eye associated with dryness of the eye, difficulty in concentrating gaze and difficulty in reading since 7 years. At the onset of symptoms, she had consulted an allopathic doctor. As suggested by the allopathic doctor, an MRI Brain was done that did not reveal any anomaly and Acetylcholine Aeceptor Antibody test yielded non-significant results. The biomedical diagnosis was made as Blepharospasm based on the clinical evaluation. She underwent standard of care for 2 years, but the condition persisted. After another 5 years, she decided to try Ayurvedic treatment. She approached Dr Anupama Deopujari. Based on clinical evaluation, the biomedical diagnosis was confirmed as Blepharospasm, and the ayurvedic diagnosis as Nimesha vyadhi. The line of treatment followed was vatanashaka, mamsabalavardhaka and balya. Formulations to strengthen the mamsa dhatu were included in the treatment. With one month of treatment, the complaint of dryness reduced, and blinking slightly reduced. With one month of treatment, the complaints of dryness reduced, and blinking slightly reduced. After 1 year and 8 months of treatment, there was a significant reduction in blinking frequency and the deviation of gaze was reduced. The dryness of eyes was completely cured and there was significant improvement in reading capacity. This case report demonstrates the successful ayurvedic management of a chronic case of blepharospasm in a 57 year old female, who did not get relief inspite of taking standard of care for 2 years.