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A 66 year old male patient presented with bilateral knee joint  pain, right greater than left since 3 months associated with crepitation in right knee joint and difficulty in climbing stairs since 1 month . Patient also had low back stiffness since 30 years. He had tried ayurvedic medicines for 2 months. As there was no relief, the patient approached Dr Partap Chauhan for a second ayurvedic consultation. Based on the ACR criteria for early diagnosis of Osteoarthritis of the knee, the treating physician made the biomedical diagnosis as osteoarthritis of knee and Ayurveda diagnosis as Sandhivata. The line of treatment planned was to pacify the primary vitiated vata dosa and primary symptom- vedana. Apart from this, rakta shodhana, deepana, pacana, and recana dravya were included in the treatment. the After 4 months of Ayurvedic treatment, the patient attained complete relief from the knee joint pain and crepitus. He could climb the stairs without any pain. The persisting low back stiffness since 30 years had significantly reduced after the treatment. The WOMAC scale assessment score before treatment was 64, which was reduced to 1 after treatment. This case report demonstrates the successful standalone ayurvedic management of osteoarthritis of knees in an elderly male, who did not get relief with conventional medicines.