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A 25-year-old female patient presented with dry skin patches with itching and redness over the scalp, right knee, right hand and chest region associated with irregular menstruation and excessive weight gain since 3 years. There was a temporary relief in the itching, but the patches kept on increasing in size over time despite taking alternative treatments, and hence she opted for Ayurvedic management. She approached Dr Partap Chauhan for better management. Based on the clinical evaluation, the biomedical diagnosis was made as Plaque psoriasis and Ayurvedic diagnosis as Eka kushta. The line of treatment followed was tridosa shamana, rakta shodhana and prasadana, sroto shodhana and shothaghna cikitsa. After 6 months of ayurvedic treatment, there was a significant reduction in symptoms, and in 7 months, she was completely relieved from all the associated symptoms. PASI documented as 4.4 at midpoint reduced to 0.1 at endpoint. This case report demonstrates the successful ayurvedic management of a chronic case of plaque psoriasis in a patient who was not getting relief with conventional medicines.