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A 35-year-old female patient presented with mild continuous headaches which became severe on and off with nausea, vomiting and irritation for 15 years. Sometimes associated with poor eyesight since 1 month. In spite of taking other standard of care, the condition persisted and hence she opted for Ayurvedic treatments and approached Dr Partap Chauhan. Based on the clinical evaluation, the physician diagnosed the condition as migraine and Ayurvedic diagnosis as Shirashoola. The line of treatment followed was Vata, pitta and vedana shamaka. Medhya and rasayana cikitsa was also incorporated. In 1 month, there was a significant relief from mild continuous headache, severe on and off headache. The nausea and vomiting during headache, also reduced. With 5 months of treatment, the patient got complete relief from all the symptoms. This case report demonstrates the successful standalone ayurvedic management of a chronic case of migrane, that was not responsive to standard of care in allopathy and homeopathy.