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A 30-year-old female patient presented with recurrent episodes of regurgitation and abdominal pain for 2 years. The pain is unbearable and associated with vomiting for 1 year for which she took analgesics and would get temporary relief. The USG done revealed a gall bladder calculi of size 24 mm. Based on the USG report, the biomedical diagnosis was made as Cholelithiasis. She opted for Ayurvedic management and approached Dr Jyoti Joshi. The ayurvedic diagnosis was made as Pittashmari. The line of treatment followed was Virecana to induce pitta shamana and to dissolve the ashmari. With 3 weeks of Ayurvedic treatments, the patient could get significant relief from the abdominal pain and regurgitation. With 4 months of treatment, the patient was relieved from all the symptoms and the repeat USG revealed normal gall bladder with no calculi. This case report demonstrates the successful standalone ayurvedic management of a chronic case of Cholelithiasis in a patient who was not getting relief from symptoms despite taking conventional medicines.