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A 45-year-old male patient pre-diagnosed with diabetes mellitus and on anti-diabetic medicines presented with frequent urination for 2 weeks associated with disturbed sleep, experiencing excessive thirst, fatigue, lethargy and loss of body weight. At the onset of symptoms, he had consulted an allopathic doctor who confirmed the Biomedical diagnosis as Diabetes mellitus. He started anti- diabetic medicines, but the symptoms persisted. Hence he decided to consult Dr Partap Chauhan for Ayurvedic management. The ayurvedic diagnosis was Madhumeha. The line of treatment followed was Vata- kapha shamana and Pitta- vata shamana. The treatment also targeted Sroto shodhana and rasayana karma. With 2 months of Ayurvedic treatment along with specific diet and lifestyle modifications, the frequency of urination during the night was reduced and the patient got significant relief from the associated symptoms. After 3 months of treatment, the patient had no specific symptoms. The HbA1c that was recorded as 13.6 at baseline became 6.1 at endpoint. The patient could stop all his anti-diabetic medications. This case report demonstrates the successful ayurvedic management of a case of Diabetes mellitus in a patient who was not getting satisfactory outcomes inspite of taking anti-diabetic medications.