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A 43-year-old male patient complained of a painless hard mass in the left axillary region that was slowly progressing since the past 2 months. He consulted Dr Aditya Mishra via telephone and took ayurvedic medicines for 20 days, but did not get relief. So he consulted an allopathic doctor and took conventional medicine for a few days, but the symptom did not resolve. He restarted ayurvedic treatments and was referred to a Modern Hospital for detailed investigations. FNAC, PET Scan and Biopsy done confirmed the biomedical diagnosis as Diffuse Large B cell Lymphoma- stage 3, and was scheduled for Chemotherapy. The Ayurvedic diagnosis was Mamsa arbuda. The line of treatment adopted was Tridosa shamana specifically kapha and pitta hara. Dipana- Pacana, medhya and rasayana dravyas were also given. Along with chemotherapy, ayurvedic treatments were integrated with specific dietary recommendations and psychotherapy. This integrative approach could minimise the side effects during CT, no delay in CT and no secondary infections reported. The Scored Patient- Generated Subjective Global Assessment, revealed that the quality of life of the patient could be enhanced. The Deauville Score that was documented as 3 at baseline, became 1 at endpoint. This case report portrays the successful integrative management of DLBCL with Chemotherapy, ayurveda, diet, psychotherapy, and specific use of functional food.