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A 39-year-old female patient pre- diagnosed with ALS presented with severe pain associated with restricted movements of her right upper and lower limb which makes her day-to-day activities strenuous since 1 year. She feels like choking while swallowing food, has trouble eating, drooling of saliva and her food intake has reduced drastically.  Her quality of life is badly affected as she is always disturbed by poor sleep due to her symptoms. She had tried conventional medicine but did not get relief. She now approached Dr Zankhana for ayurvedic management. The ayurvedic diagnosis was Vatavyadhi- Mastishka majja kshaya. The line of treatment followed was Sroto shodhana, dosa recana, shirogata vata shamana, balya and brmhana. After 15 days of Ayurvedic treatment, there was a noticeable reduction in her symptoms. Following 25 days of treatment, the patient experienced significant improvement in her clinical condition and overall quality of life. This case report demonstrates the successful ayurvedic management of ALS in a patient helping to improve the quality of life.