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A 57-year-old female patient, presented with difficulty in swallowing food, loss of appetite and significant weight loss for 4-5 months. She was able to take only a soft diet and liquids. She aslo had abdominal pain on & off. There was no prior consultation. The patient consulted Dr Zankhana, who recommended Invasive investigations like OGD/HPE/PET-CT Scan. Based on the reports, the biomedical diagnosis was confirmed as moderately differentiated squamous cell carcinoma of the esophagus, grade -2. She was directed to an Oncologist, who advised Chemotherapy and Radiation therapy followed by surgical resection. . An integrative approach was advocated for the management of this clinical condition. The Ayurvedic diagnosis was Arbuda.  The line of ayurvedic treatment followed was dipana, pacana, balya and ojo vardhana. The medicines also targeted at addressing the symptoms like lack of sleep, colic and stress. The Chemo and radiation therapy were also carried on as scheduled by her oncologist. Based on the Patient-reported outcome scale and the Physician outcome scale, it was evident that there was a significant change in the symptoms. After 1 month of treatment, she was able to take solid food. There were no episodes of vomiting or burning sensation in the abdomen. VAS recorded 10 at baseline reduced to 3. After 2 months of treatment, there was a significant improvement in the WBC and platelet count. After 3 months of treatment,  she underwent surgery for tumour removal. Last follow-up done was after 7 months, which revealed the patient was fully back to her normal routine. PET revealed a tumor-free status. This case report demonstrates the successful intergrative management of Esophageal cancer.