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A 64-year-old female patient was a known diabetic for 14 years and hypertension for 5 years. She is on allopathic medication for diabetes and hypertension. She complains of frothiness of urine and bilateral ankle swelling since 6 months. She did not consult any allopath for this specific symptom. She consulted Dr Indu for Ayurvedic management. Based on the lab investigations, the biomedical diagnosis was made as Microalbuminuria in Diabetes Mellitus. Based on the clinical evaluation, the ayurvedic diagnosis was made as Prameha janya abhyantara vidradhi pidaka. The line of treatment followed was prameha hara. With one month of Ayurvedic treatment, the 24 hour Microalbumin level – 100 mg/day at baseline became 30 at endpoint level reached within normal limits and the patient got relief from all the symptoms. This case report highlights the clinical efficacy of ayurveda in treating Micro albuminuria using a simple single formulation.