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A 19-year-old male patient presented with itching and dandruff on the scalp for 4 years associated with scaling, dry skin lesions, and itching over the entire body for 2 years. There were no prior treatments. The patient consulted Dr Partap Chauhan for the management of this condition. Based on the clinical evaluation, the biomedical diagnosis was made as Xeroderma and the Ayurvedic diagnosis was Darunaka. The line of treatment was Vata-pitta, vata-kapha, tridosa shamana, sroto shodhana and rasayana cikitsa. With 7 months of Ayurvedic treatment, the patient got complete relief from symptoms. This case report is an example for the successful ayurvedic management of a case of Xeroderma in a patient with a chronic history.